多种物质的使用和胰腺炎的风险:系统审查
Esther A Adeniran1, Yi Jiang2, Dhiraj Yadav3
1Department of Biomedical Sciences, Cedars-Sinai Medical Center, 6500 Wilshire Blvd, 15th Floor, 1544B, Los Angeles, CA 90048, USA.
Therapeutic advances in gastroenterology
|August 28, 2025
概括
与使用单一物质相比,饮酒与吸烟的联合会显著增加胰腺炎的风险. 吸烟与酒精相结合时对胰腺炎风险产生剂量依赖的影响,这凸显了对其他物质组合的进一步研究的需要.
科学领域:
- 胃肠病学
- 公共卫生
- 毒理学
背景情况:
- 多种药物对胰腺炎风险的影响尚不清楚.
- 之前的研究还没有全面评估各种物质对胰腺健康的综合作用.
研究的目的:
- 系统地审查多种物质使用与急性胰腺炎 (AP) 或慢性胰腺炎 (CP) 风险之间的观察研究.
- 综合现有证据,说明烟草,酒精,大麻和非法药物如何影响胰腺炎的风险.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 在EMBASE,MEDLINE和PsycINFO数据库中进行了搜索,直到2024年3月.
- 包括11项研究,研究两种或多种物质与AP或CP的关联,并对质量进行了评估.
主要成果:
- 酒精和烟草的联合使用增加了AP和CP的风险,报告的相对风险和赔率比率具有显著的异质性.
- 当与酒精同时使用时,吸烟表明胰腺炎风险的剂量依赖增加.
- 一项研究表明,与单独的酒精相比,大麻和酒精的联合使用可能会降低AP的风险.
结论:
- 同时使用酒精和烟草会比单次使用增加胰腺炎的风险.
- 吸烟对胰腺炎风险的影响与酒精相结合时取决于剂量.
- 需要更多的研究来了解其他物质对胰腺炎风险的影响.
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