高度质瘤儿科患者的静脉血栓栓塞风险因素:多中心回顾性研究
Yanxia Chen1, Wenjing Fei2, Yaqin Shi1
1Department of Neurosurgery, The 904th Hospital of PLA, Medical School of Anhui Medical University, Wuxi, China.
Frontiers in pediatrics
|August 28, 2025
概括
儿科高度质瘤患者患有静脉血栓塞栓症 (VTE) 的风险很高. 诸如瘤特征和治疗等因素会影响静脉瘤,从而对存活率产生负面影响,因此需要针对性的预防策略.
科学领域:
- 儿童瘤学
- 血液学
- 神经瘤学
背景情况:
- 静脉血栓塞栓症 (VTE) 是儿童高度质瘤 (pHGG) 患者的一个关键并发症.
- 了解患有静脉瘤的独特儿童风险因素对于有效的治疗至关重要.
研究的目的:
- 确定与小儿高度质瘤相关的风险因素和临床特征.
- 分析VTE对该群体的预后和生存的影响.
主要方法:
- 168名pHGG患者的多中心回顾分析 (2012年1月至2024年1月).
- 从电子病历收集的数据,包括静脉瘤发生率,临床细节和结果.
- 统计分析包括t测试,曼-惠特尼U测试,奇平方和考克斯回归模型.
主要成果:
- 37. 5% 的患者出现了静脉突发症.
- 抗静脉血栓炎的保护因素包括抗凝血,IDH1突变,MGMT甲基化,放射治疗,化疗和减少床上休息.
- 静脉瘤的危险因素包括瘤体积增加,4级质瘤,EGFR阳性,p53突变,葡萄糖皮质激素治疗和中央静脉导管放置.
- 静脉瘤发生与平均存活时间为51. 4个月有关,并对预后产生负面影响.
结论:
- 这项研究确定了儿科高度质瘤的关键风险因素.
- 针对性预防和治疗策略对于管理VTE和改善结果至关重要.
- 临床特征,遗传特征和治疗方式对于pHGG患者的静脉瘤治疗至关重要.
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