作为生物标志物的声音:对良性和恶性声病变的探索性分析
Phillip Jenkins1, Rylan Harrison2, Steven Bedrick1
1Division of Informatics, Clinical Epidemiology, Oregon Health and Science University, Portland, OR, United States.
Frontiers in digital health
|August 28, 2025
概括
声音生物标志物如声比率 (HNR) 可以帮助早期发现声损伤. 这项研究发现HNR和基本频率能将良性和恶性病变与健康的声音区分开来,特别是在男性中.
科学领域:
- 喉科 喉科
- 声学分析
- 生物标志物的发现
背景情况:
- 无论是良性还是恶性,声损伤都会对声音质量产生重大影响,并可能导致严重的健康后果.
- 这些病变的早期非侵入性检测对于改善患者的治疗结果和诊断的可用性至关重要.
- 语音分析提供了一个潜在的生物标志物来识别喉病理.
研究的目的:
- 识别声学特征,以最好地区分喉癌和良性声病变与其他声音状况和健康的声音功能.
- 评估语音作为早期病变检测的非侵入性生物标志物的实用性.
主要方法:
- 分析 Bridge2AI-Voice 数据集,包括七个诊断队列.
- 使用非参数统计方法提取和比较声学特征 (基本频率,动,闪,HNR).
- 两层分析: (1) 喉癌,良性病变,健康的声音; (2) 喉癌,良性病变,性失声,声麻.
主要成果:
- 在良性病变和健康对照者/喉癌之间发现了声比率 (HNR) 和基本频率的显著差异.
- 这些区别,特别是HNR及其可变性,也在男性中被观察到.
- 在非性别女性中,有限的样本大小排除了统计学意义上的发现.
结论:
- 声调与噪声比 (HNR),特别是其变性,显示为早期检测和监测声损伤的基于语音的标志物.
- 声学语音分析可以帮助区分良性和恶性声状况.
- 为了验证这些发现及其临床应用,需要对更大,更多样化的群体进行进一步研究.
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