骨转移和疼痛研究通过文献计量和生物信息学的双重视野:知识结构,边界和核心途径分析 (2015-2024年)
在PubMed上查看摘要
概括
此摘要是机器生成的。这项研究分析了骨转移和癌症疼痛研究的趋势,确定了针对新型疼痛管理策略的精确疗法和关键分子点的转变.
科学领域
- 癌症学
- 疼痛研究
- 生物信息学
- 图书识别技术
背景情况
- 癌症引起的骨痛 (CIBP) 具有复杂的潜在机制,具有重大临床挑战.
- 目前对CIBP的治疗方法往往不足以有效控制许多患者的疼痛.
- 了解骨转移和疼痛的研究趋势对于推进治疗策略至关重要.
研究的目的
- 确定骨转移和疼痛研究的关键研究趋势,主题和未来方向,从2015年至2024年.
- 确定骨转移和癌症疼痛病变的核心基因和信号通路.
- 探索研究从传统的缓解护理到精确干预的演变.
主要方法
- 从科学网络核心集合中对1822份文档进行了图书统计分析.
- 对与骨转移和癌症疼痛相关的核心基因进行生物信息查.
- 对基因功能和相关信号通路的分析.
主要成果
- 骨转移和疼痛的全球研究成果显示出越来越多的趋势,主要是美国和中国.
- 研究重点正在转向精确疗法,包括立体性身体放射疗法和最小侵入性切除.
- 在骨转移和疼痛中确定了关键基因 (例如TP53,EGFR) 和通路 (例如PI3K-Akt,MAPK,TNF).
- 神经病痛机制正成为一个重要的研究前沿.
结论
- 这项研究提供了骨转移和疼痛研究演变的全面概述,使用了结合的文献计量和生物信息方法.
- 确定了分子点和途径,为开发针对瘤进展和疼痛缓解的新疗法提供了有希望的途径.
- 这些发现突显了CIBP研究的准确医学和机制理解的转变.
相关概念视频
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

