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基于OCTA视网膜微血管参数的冠状动脉疾病的早期诊断

Shijia Zhou^1,2, Qifeng Yan¹, Jiaqi Guo¹

¹Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, China.

Frontiers in cell and developmental biology

|August 28, 2025

概括

在患有冠状动脉疾病 (CAD) 的患者中,光学连贯性断层扫描 (OCTA) 显示了视网膜微血管复杂性的减少. 这些OCTA生物标志物显示出早期CAD诊断和风险分层的潜力.

科学领域:

眼科眼科
心脏病学
医学成像

背景情况:

冠状动脉疾病 (CAD) 是全球心血管死亡的主要原因.
早期诊断CAD对于有效的预防和治疗策略至关重要.
视网膜微血管变化可能反映系统血管健康,提供诊断潜力.

研究的目的:

研究OCTA衍生的视网膜微血管参数与CAD之间的关联.
评估OCTA作为早期CAD检测的非侵入性工具.

主要方法:

分析了747名参与者的OCTA图像 (332名CAD,415名对照).
视网膜微血管参数的提取和定量,包括血管密度,长度密度,曲率和分叉复杂性.
在CAD患者和对照人群之间的参数统计比较.

主要成果:

与对照组相比,患有CAD的患者表现出明显较低的视网膜血管密度,血管长度密度,曲度和血管分叉复杂性.
这些差异在左眼中特别明显,表明横向不对称.
由OCTA衍生的生物标志物与CAD状态有关.

结论:

可以检测与CAD相关的视网膜微血管结构的显著变化.
来自OCTA的视网膜微血管生物标志物对早期CAD诊断和风险评估具有前景.
基于OCTA的视网膜生物标志物可能成为临床实践中评估心血管健康的宝贵工具.

关键词:

生物标志物冠状动脉疾病光学连贯断层扫描血管学视网膜微血管参数视网膜血管系统

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