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生物库利用的障碍和机遇:韩国微生物组生物库网络对女性乳腺和生殖器疾病的三年重复横截面调查的见解

Sangzin Ahn^1,2, Hwa Jin Cho³, Mi-Seon Kang³

¹Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, Korea.

Journal of Yeungnam medical science

|August 28, 2025

概括

尽管研究人员的参与度很高, 生物库在韩国面临着复杂的访问和有限的知识挑战. 简化程序和加强教育是未来研究成功的关键.

科学领域:

生物医学研究
生物银行
微生物组研究

背景情况:

通过微生物组生物库网络 (FDMNet) 调查韩国女性乳腺和生殖器疾病的生物库利用模式,挑战和机会.
利用2022-2024年的年度调查来评估研究人员的意识,访问障碍和对微生物组研究的兴趣.

研究的目的:

记录和分析生物库利用的现状.
确定阻碍有效使用生物库的关键障碍.
探索改善生物库运营和研究人员支持的机会.

主要方法:

在五所大学医院对155名工作人员进行了在线调查,
使用描述性统计数据进行定量数据分析.
利用统一多重近似和投影 (UMAP) 和自然语言处理进行定性反分析以识别用户挑战.

主要成果:

初始参与率高 (76%),但在医疗保健危机期间,特别是在2024年,参与率和合作率有所下降.
主要使用障碍包括复杂的访问程序 (31.0%),缺乏流程知识 (23.9%) 和机构审查委员会 (IRB) 的担忧 (11.6%).
乳腺和女性生殖器瘤是主要研究领域; 血液和组织样本是最需要的. 对微生物组研究有很大的兴趣 (66.5%),但知识不足.

结论:

简化生物银行准入程序至关重要.
需要加强研究人员的教育和改善临床数据的整合.
需要更强大的治理结构来克服利用障碍并支持不断变化的研究需求.

关键词:

生物库的使用生物标本微生物组韩国共和国研究障碍

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