儿童喘的患病率和危险因素:系统性审查和元分析
Li Yin1, Feifei Zhang2, Xue Wang1
1Department of Pediatrics, Second Hospital of Hebei Medical University, Shijiazhuang, China.
概括
儿童喘影响11.9%的儿童. 主要危险因素包括产前接触某些化学物质和药物,以及童年Helicobacter pylori感染,而叶酸可能具有保护作用.
科学领域:
- 儿童呼吸系统医学
- 环境健康
- 流行病学
背景情况:
- 儿童喘 (CA) 是一个复杂的公共卫生问题.
- 了解患病率和风险因素对于有效的预防和管理策略至关重要.
研究的目的:
- 进行分析,评估儿童喘的患病率.
- 确定与儿童喘发展相关的关键风险因素.
主要方法:
- 在2015年至2024年间发表的综合元分析.
- 搜索了PubMed,Embase,Cochrane和科学网络的数据库.
- 包括45项与647,414名参与者的研究,使用NOS评估研究质量,并使用Stata和R分析数据.
主要成果:
- 儿童喘的综合患病率为11. 9%.
- 确定的危险因素包括产前暴露于和多基物质 (PFAS) (OR=0. 89),抑制酸性的药物 (OR=1. 11),以及儿童的Helicobacter pylori感染 (OR=2. 07).
- 孕妇在怀孕期间服用叶酸补充剂显示有保护性关联 (OR=1.18).
结论:
- 儿童喘患病率很高,因此需要对已确定的风险因素进行进一步研究.
- 产前暴露和感染起作用,而叶酸可能会提供保护.
- 建议进行进一步的大规模前性研究以阐明这些关联.
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