患有肌痛性肌痛症的患者多次同时发生的机会性感染:病例报告
Jingrou Chen1,2, Jingchun Fang1,2, Li Sun3
1Department of Laboratory Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Virulence
|August 28, 2025
概括
这份病例报告详细介绍了一名患有骨髓灰质炎的患者在免疫抑制治疗后出现严重的胃肠道出血和多种机会性感染. 这些复杂感染的早期发现和综合治疗对于患者的结果至关重要.
科学领域:
- 临床医学
- 免疫学
- 传染性疾病
背景情况:
- 肌痛性肌痛症 (MG) 是一种罕见的自身免疫性疾病,预后不佳,特别是当因机会性感染而复杂时.
- 在MG患者中,免疫抑制疗法增加了严重和多重感染的风险,这带来了重大的临床挑战.
研究的目的:
- 分析一个中年男性患者的临床病例,该患者在免疫抑制治疗后出现了严重的胃肠道下部出血和多次机会性感染.
- 突出MG患者同时存在的感染的诊断和治疗复杂性.
主要方法:
- 综合性临床评估包括结肠镜,组织病理学,支气管镜,支气管支气管洗 (BAL) 和下一代代代码测序 (mNGS).
- 组织病理学检查证实了细胞巨病毒 (CMV) 和细胞质.
- 在BAL液体和mNGS中发现了Aspergillus fumigatus,Talaromyces,Stenotrophomonas maltophilia和Pneumocystis jirovecii的感染.
主要成果:
- 患者出现了持续的肺,肺部感染和严重的下胃肠道出血.
- 发现了多种病原体,包括CMV,Histoplasmosis,Aspergillus,Talaromyces,S. maltophilia和P. jirovecii.
- 治疗需要适应广泛的抗感染药物和支持性治疗,包括免疫球蛋白和白蛋白.
结论:
- 接受免疫抑制治疗的MG患者需要对机会性感染进行警监测.
- 在MG中同时处理多种病原体是复杂的,需要多方面的方法.
- 使用像mNGS这样的先进技术进行及时准确的诊断对于有效的治疗策略至关重要.
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