老年人的外周与中心动脉硬和心血管事件:社区动脉样硬化风险 (ARIC) 研究
Tatsuhiro Shibata1, Yejin Mok1, Shoshana H Ballew2
1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
European journal of preventive cardiology
|August 28, 2025
概括
周围动脉硬 (faPWV) 与心血管疾病 (CVD) 有相反的相关性,而中心动脉硬 (cfPWV) 则具有积极的相关性. cfPWV与faPWV的比率 (cf-fa比率) 可以更好地预测心脏病风险.
科学领域:
- 心血管医学
- 生物医学工程
- 流行病学
背景情况:
- 动脉脉冲波速度 (cfPWV) 测量中心动脉硬性,并预测心血管疾病 (CVD).
- 股骨脉冲波速度 (faPWV) 测量了外围动脉硬,但其与心血管疾病的关联程度较少.
研究的目的:
- 调查faPWV和cfPWV与发生心血管疾病的关联.
- 为了比较cfPWV,faPWV的预后值及其对心脏病风险的比率 (cf-fa比率).
主要方法:
- 对3402名ARIC参与者进行分析,
- 使用Omron VP-1000 Plus测量faPWV和cfPWV.
- 用于评估心血管疾病 (CHD,HF,中风) 中位数为9.0年的随访期的多变量Cox比例危险模型.
主要成果:
- 在完全调整后,faPWV与心血管疾病有相反的相关性 (p- for- trend=0. 096).
- cfPWV与心血管疾病有正相关性 (上下四分位数的HR为1. 22,趋势的p=0. 043).
- 对心血管疾病的相关性比对cfPWV的相关性更强 (HR1. 37, p- for- trend=0. 005),特别是在心力衰竭方面.
结论:
- 中心和外围动脉硬对心血管疾病有不同的预后影响.
- 心血管风险评估中的CF-fa比率可能是一个有价值的工具.
- 结果支持cf-fa比率作为CVD风险分层的替代措施.
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