在使用GLP-1受体激活剂的成年人中检测腺瘤和形形息肉的比率
Samita Garg1, Din Hoxha2, David Long1
1Department of Gastroenterology, Hepatology & Nutrition, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH.
Clinical and translational gastroenterology
|August 28, 2025
概括
葡萄糖类-1受体激活剂 (GLP-1RA) 的使用与结肠镜准备较差有关,特别是在糖尿病患者中. 这可能会减少状多体的检测,但不影响腺瘤的检测.
科学领域:
- 胃肠病学
- 内分泌学
- 药理学
背景情况:
- 葡萄糖类-1受体激动剂 (GLP-1RA) 广泛用于糖尿病和肥胖症的治疗.
- GLP- 1RA可以延缓胃肠运动,可能会影响肠道准备结肠镜检查的质量.
- 不充分的肠道准备增加了结肠镜检查期间缺失结肠直肠病变的风险.
研究的目的:
- 研究GLP-1RA使用对肠道准备质量的影响.
- 评估GLP-1RA对腺瘤和状腺瘤检测率的影响.
主要方法:
- 在49987名接受结肠镜检查的患者中进行了回顾性队列研究.
- 在GLP-1RA使用者 (n=4,269) 和非使用者 (n=45,718) 之间的比较.
- 使用倾向性评分权重来控制混因素;根据糖尿病状况进行分组分析.
主要成果:
- 使用GLP- 1RA与肠道不充分准备的可能性增加了23% (OR1.23).
- 在使用者和非使用者之间没有明显的腺瘤或SSP检测率差异.
- 在糖尿病患者中,GLP- 1RA使用显示出更高的准备不足率 (OR1. 88) 和较低的SSP检测率 (OR0. 71).
结论:
- 使用GLP- 1RA与肠道准备不足的可能性增加,特别是在糖尿病患者中.
- 在糖尿病GLP-1RA使用者中观察到较低的SSP检测率.
- 对糖尿病GLP-1RA使用者进行量身定制的肠道准备方案的前性评估是有必要的.
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