优化化疗实践:剂量区分对再发放和废物减少的影响
Alida Geertruida Catharina van Huët1,2, Helle-Brit Fiebrich-Westra3, Peder Nygård1
1Department of Pharmacy, Isala Hospital, Zwolle, Netherlands.
概括
像帕克利塔克塞尔和氧沙利普拉丁这样的化疗剂的剂量范围增加了混合物再发放,并显著减少了药物浪费. 这一举措提高了医疗保健的可持续性和成本效益,每年节省约5200欧元.
科学领域:
- 癌症学
- 制药科学
- 医疗保健管理
背景情况:
- 由于精确的剂量要求,化疗制备通常会导致浪费.
- 复制化疗剂的互换性有限,影响了可持续性.
- 剂量划分旨在减少浪费并提高癌症治疗的成本效益.
研究的目的:
- 评估剂量区分对化学疗法添加剂再发放的影响.
- 评估剂量范围对减少药物浪费的影响.
- 量化实施剂量范围的经济效益.
主要方法:
- 在Hix 6. 2中实施了最大10%偏差的剂量范围.
- 药物废弃物和添加剂的再发行在实施前和后进行了比较.
- 经济效益是根据产品,材料和制备成本计算的.
主要成果:
- 对于大多数药物,特别是氧沙,化学疗法添加剂的再发行增加了 (3.7%至27.8%).
- 包括帕克利塔塞尔在内的药物浪费显著减少 (90至23种混合物).
- 每年节省了大约5200欧元的成本.
结论:
- 剂量划分增强了化疗剂的可互换性,导致再发放的增加.
- 这种方法有效减少化疗制备中的药物浪费.
- 更广泛地实施剂量区分可以进一步优化化疗服务.
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