酸特异性酸 (Kgp) 的P. 通过禁用干扰素途径促进病毒感染
Ewelina Dobosz1, Anna Golda1,2, Michal Kanoza1,3
1Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
mBio
|August 28, 2025
概括
牙周炎 (PD) 通过破坏干扰素反应,增加病毒传播,加剧了简单疹病毒-1 (HSV-1) 感染. 一个关键的PD病原体 Porphyromonas gingivalis 使用Kgp gingipain来削弱抗病毒防御,促进HSV-1的传播和重新激活.
科学领域:
- 口腔微生物学和免疫学
- 病毒学
- 传染性疾病
背景情况:
- 牙周炎 (PD) 是一种常见的慢性炎症疾病,与各种系统性疾病,包括病毒感染的风险增加有关.
- 临床观察显示,牙周炎患者的病毒感染频率较高,特别是疹病毒,但潜在的机制尚不清楚.
- 口腔粘膜中抗病毒反应受损是牙周炎和病毒感染之间观察到的并发症的潜在解释.
研究的目的:
- 调查牙周炎的主要原因 - - Porphyromonas gingivalis对简单疹病毒-1 (HSV-1) 感染的发展和传播的影响.
- 阐明P. gingivalis影响宿主抗病毒防御系统的分子机制,特别是干扰素反应.
主要方法:
- 使用人类牙模型研究P. gingivalis和HSV-1感染之间的相互作用.
- 研究了P. gingivalis的囊蛋白酶Kgp gingipain在调节宿主信号通路中的作用.
- 研究了P. gingivalis对神经细胞中的HSV-1重新激活的影响.
主要成果:
- 在人类牙模型中,Porphyromonas gingivalis显著增加了HSV-1感染,促进了病毒组织分布和传播.
- 通过蛋白质分析改变关键信号组件,P. gingivalis的Kgp痛蛋白酶会损害干扰素依赖的抗病毒反应.
- 通过干扰素独立的机制,P. gingivalis还促进了神经细胞中的HSV-1重新激活.
结论:
- Porphyromonas gingivalis 积极减弱宿主的抗病毒防御,从而促进了简单疹病毒-1 的感染和传播.
- 这些发现揭示了一种涉及Kgp gingipain的新型分子机制,解释了牙周炎和HSV-1等病毒感染之间的共患性.
- 这项研究强调牙周炎是由于宿主防御机制受损而导致病毒感染的潜在通道.
相关概念视频
GPCRs Regulate Adenylyl Cylase Activity
5.9K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.9K
Immune Response Against Viral Pathogens
917
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
917
Activation and Inactivation of G Proteins
7.6K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
7.6K
Gene Regulation in Microbial Communities: Quorum Sensing
92
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
92


