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对抗血管生成疗法的反应与质母细胞瘤和低级质瘤中的AIMP蛋白家族表达有关

Humaira Noor¹, Yuanning Zheng¹, Haruka Itakura²

¹Stanford University, Palo Alto, United States.

Cancer research communications

|August 28, 2025

概括

氨基酸tRNA合成酶复合相互作用的多复合蛋白 (AIMPs) 显示为预测性生物标志物,用于质母细胞瘤的抗血管治疗. 高AIMP2表达与更好的治疗反应相关,有助于患者分层以改善结果.

科学领域:

癌症学
分子生物学
遗传学

背景情况:

质母细胞瘤 (GBM) 是一种高度血管化的瘤,其抗血管生成疗法有效性有限.
预测生物标志物对于针对性治疗的GBM患者分层至关重要.
氨基酸tRNA合成酶复合相互作用多复合蛋白 (AIMPs) 1/2/3在质瘤中的作用及其与血管生成的关联尚未研究.

研究的目的:

研究AIMP1/2/3与质瘤血管生成的相关性.
评估AIMP作为抗血管原治疗反应的预测生物标志物.
在GBM中探索AIMP2的空间和细胞类型特异性表达.

主要方法:

对质瘤样本 (TCGA,CGGA,Rembrandt,Gravendeel,BELOB,REGOMA) 和单细胞转录组数据进行多队列的回顾性分析.
多基因分析包括转录基因,表观基因和蛋白质基因数据.
预测价值评估的卡普兰-梅尔和考克斯比例危险模型;空间表达分析的单细胞转录组学.

主要成果:

在TCGA癌症中,AIMP1/ 2/3表达与血管生成相关,在质瘤中与正常组织相比,高度与低度,复发与初级瘤相比,上调.
在GBM临床试验 (REGOMA,BELOB) 中,高AIMP2的小组对抗血管生成疗法的反应得到改善.
鉴定出AIMP2- cg04317940甲基化是临床适用的分层标志物,在瘤组织,特别是AC类细胞中具有同质的AIMP2表达.

结论:

在质瘤血管生成中,AIMPs起着重要作用.
在GBM中,AIMP2及其甲基化状态可以作为抗血管治疗反应的预测生物标志物.
这些发现支持改善复发性GBM患者分层和治疗策略.

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