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Updated: Sep 9, 2025

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作为高度选择性和口服可用的EGFRL858R/T790M/C797S 抑制剂的直接Ser797交互的Pteridine-7(8H-one衍生物

Wenzhe Jiang1, Yupei He1, Yongxiang Wang1

  • 1School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

Journal of medicinal chemistry
|August 28, 2025
PubMed
概括

一种名为M49的新药有效向导致非小细胞肺癌 (NSCLC) 对奥西默蒂尼布耐药性的EGFR突变. 这种强大的抑制剂有望克服耐药性并改善患者的治疗结果.

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