在风湿性视网膜脱落中异常的白灰质功能合:静止状态功能MRI和机器学习的证据
1Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
Neuroreport
|August 28, 2025
概括
视网膜脱落 (RRD) 改变了白质活动及其与灰质的联系. 内部囊前肢的升高信号显示为RRD的诊断生物标志物.
科学领域:
- 神经成像
- 神经科学
- 眼科 眼科
背景情况:
- 新出现的证据表明,白质中的血氧水平依赖的信号反映了功能活动.
- 目前尚不清楚白质功能是否受到性视网膜脱落 (RRD) 的改变,以及它与灰质的相互作用.
研究的目的:
- 在RRD患者中调查白质活性和灰质连接性.
- 确定异常的白质区域及其诊断用途.
主要方法:
- 休息状态功能性MRI (fMRI) 用于分析白质中低频波动/ 分数ALFF (ALFF/ fALFF) 的幅度.
- 评估了跨组织白质灰质的功能连接性.
- 支持矢量机器模型用于评估诊断性能.
主要成果:
- 患有RRD的患者在前冠状辐射 (ACR) 和内前肢 (ALIC) 中呈现ALFF/ fALFF的增加.
- 在左侧ACR和非视觉灰质区域之间发现了增强的功能连接.
- 左ALIC的fALFF值实现了高分类性能 (AUC=0.8974) 区分RRD.
结论:
- RRD与异常的自发低频活动和增强的白质灰质合有关.
- 这些发现表明RRD超出视网膜的跨组织功能重组.
- 在左ALIC中增加的fALFF显示为RRD的神经成像生物标志物.
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