额外的心电图指标对心脏沙丘病患者预后的有用性
Junichi Kamoshida1, Kohei Ishibashi2, Takanori Kawabata3
1Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Centre, Suita, Japan; Department of Cardiology, Tokyo Medical University, Nishi-shinjuku, Tokyo, Japan.
JACC. Clinical electrophysiology
|August 28, 2025
概括
高T波峰到终点 (Tp-e) / QT比率和碎片化QRS复合体 (fQRS) 预测心脏粉症患者的预后不佳和心律失常风险. 这些心电图标记对于早期风险分层非常有价值,即使在射分数保存的患者中也是如此.
科学领域:
- 心脏病学
- 电生理学
- 癌症研究
背景情况:
- 心脏瘤 (CS) 呈现出可变的腹腔复极化和脱极化.
- 已知T波峰到终点 (Tp-e) /QT比率和碎片QRS复合体 (fQRS) 是电气异常的标志物.
- 它们对CS患者的预后意义尚不完全理解.
研究的目的:
- 评估Tp-e/ QT比率,fQRS存在和日本CS患者的预后.
- 评估这些心电图标志物对心律失常风险的预测价值.
主要方法:
- 一个多中心的回顾性队列研究,利用全国性CS调查数据 (2014-2016).
- 患者根据Tp- e/ QT比率 (截止值: 0. 232) 和fQRS的存在进行分类.
- 主要结局包括全因死亡率和心室节律失常;次要结局侧重于心脏死亡率和心室节律失常.
主要成果:
- 在227名CS患者中,较高的Tp- e/ QT比率和fQRS存在与更差的预后相关.
- 多变量分析发现高Tp-e/ QT (HR: 3.01) 和fQRS (HR: 2.48) 是不良结果的独立预测因素.
- 这些心电图标记即使在左心室喷射分数 (LVEF) > 35% 的患者中也仍然是显著的预测因素 (Tp- e/ QT > 0. 232: HR: 3. 62; fQRS: HR: 3. 38).
结论:
- 升高的Tp-e/ QT比率和fQRS的存在表明CS患者的预后更差.
- 这些发现对早期心律失常风险评估尤为重要,即使在维护LVEF的CS患者中也是如此.
- 这项研究强调了Tp-e/QT和fQRS对CS风险分层的有用性.
更多相关视频
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
24.4K
10:17Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
Published on: April 11, 2025
903
相关概念视频
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
57
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
57
01:29Electrocardiogram
3.2K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
3.2K
01:30Acute Coronary Syndrome III: Diagnostic Studies
23
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
23
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
45
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
45
01:25Correlation between ECG and Cardiac Cycle
8.3K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
8.3K
01:30Cardiomyopathy II: Dilated Cardiomyopathy
21
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
21