美国中毒中心报告的midodrine暴露趋势和结果:2000-2023
David Kuai1, Daniel Philip Nogee1, Stephanie Kieszak1
1National Center for Environmental Health, Division of Environmental Health Science and Practice, Centers for Disease Control and Prevention, Atlanta, GA, USA.
据报道,从2000年到2023年,中药暴露显著增加,反映出处方的增加. 虽然大多数病例在家中得到治疗,但严重的结果发生了,特别是在疑似自杀的尝试中.
科学领域:
- 毒理学
- 药理学
- 公共卫生
背景情况:
- 米多德林是一种用于正静性低血压的α- 1上腺激动剂.
- 它的血管收缩作用可能会导致高血压和反射性心肌梗塞.
- 了解中素暴露模式对于公共卫生和临床管理至关重要.
研究的目的:
- 描述2000年至2023年间美国中毒中心报告的中毒暴露情况.
- 分析趋势,人口统计,暴露的原因和结果.
- 为了将暴露与中分发数据相关联.
主要方法:
- 从国家毒素数据系统 (NPDS) 中对单一物质 midodrine 暴露的追溯分析.
- 描述性统计评估时间趋势,人口统计,暴露原因,医疗保健利用和结果.
- 从IQVIA总患者追踪器 (2002-2023) 获得的国家门诊中素处方数据.
主要成果:
- 中药处方增加了695% (2002-2023年),报告的NPDS暴露人数为1935人 (2000-2023年).
- 暴露率增加了714% (2000-2023年),高血压 (14.3%) 和心肌梗塞 (10.2%) 是常见的特征.
- 治疗错误是最常见的,除了青少年 (自杀的怀疑,50. 2%);与自杀相关的摄入更为频繁.
结论:
- 尤其是成年人中,midodrine的暴露和发放量显著增加.
- 虽然大多数暴露在家中得到控制,但严重的不良反应需要医疗照顾,特别是在故意过量服用的情况下.
- 加强监测和临床医生的意识对于减轻与中相关的毒性至关重要.
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