检查巴雷特食道和食道腺癌:方法和结果
Natalie J Wilson1, Nicholas Mordan2, Cole Potrock3
1Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
The American journal of gastroenterology
|August 28, 2025
概括
巴雷特食道查对于早期发现食道腺癌至关重要. 新的,不那么侵入性的技术显示出更广泛的采用和更好的检测癌前病变的结果.
科学领域:
- 胃肠病学
- 癌症学
- 医疗技术
背景情况:
- 巴雷特食道 (BE) 是唯一已知的食道腺癌 (EAC) 的前体.
- 患病率急剧上升,预后不佳和晚期诊断很常见.
- 目前的内镜查对BE的采用有限,并错过了有风险的个体.
研究的目的:
- 审查EAC和BE查方面的挑战和进展.
- 评估新型的微创查技术.
- 讨论新出现的检测功能障碍症和肠道代谢症的方法.
主要方法:
- 审查当前的文献和新兴技术.
- 评估非内镜细胞采集,生物标志物,鼻腔内镜和挥发性有机化合物.
- 评估人工智能和广泛的脑外皮样本检测.
主要成果:
- 新技术为扩大查和提高检测率提供了潜力.
- 研究表明,在癌前病变的早期检测方面有希望.
- 查与降低EAC死亡率的证据仍在发展.
结论:
- 查方式的进步对于改善EAC和BE检测至关重要.
- 最少侵入性技术和人工智能有助于更广泛的采用和早期诊断.
- 需要进一步的研究和试验来优化查策略,并证明死亡率的好处.
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