酸乙醇 16:0/18:1PEth作为怀孕期间饮酒的生物标志物
E V Belyaeva1, A N Karacheva2, T A Bairova2
1Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia. belyeva_irk@mail.ru.
Bulletin of experimental biology and medicine
|August 28, 2025
概括
血中酸乙醇 (PEth) 含量可以准确地检测孕妇的酒精消耗. 这种血液标记显示饮酒量明显高于自我报告的调查, 突出了严重的公共卫生问题.
科学领域:
- 产科和妇科
- 临床化学
- 公共卫生
背景情况:
- 怀孕期间的酒精消费对胎儿的发育构成重大风险.
- 准确评估孕妇饮酒量对于干预至关重要.
- 现有的关于酒精消费的自我报告方法可能会低估实际使用量.
研究的目的:
- 评估血16: 0/18: 1酸乙醇 (PEth) 作为孕妇饮酒的生物标志物.
- 将PEth水平与通过问卷获得的自我报告的酒精使用数据进行比较.
- 通过实验室标记来确定不同妊娠季度的酒精消费率.
主要方法:
- 一项涉及309名孕妇的纵向队列研究.
- 使用T-ACE,TWEAK和AUDIT问卷来评估自我报告的酒精消费.
- 使用高性能液态染色体质谱法 (HPLC-MS) 测量血16:0/18:1的PEth水平.
主要成果:
- 61%的孕妇表示自己以前曾喝过酒.
- 在60% (头三个月),51% (第二三个月) 和49% (第三三个月) 的妇女中检测到超过8ng/ ml的血PEth水平.
- 实验室确认的饮酒频率明显高于自我报告调查显示的 (p < 0. 001).
结论:
- 血 16: 0/18: 1 PEth 是检测孕妇饮酒的可靠生物标志物.
- 通过PEth进行的客观测量显示酒精使用率高于主观问卷.
- 这些发现强调需要改善怀孕期间酒精使用的查和干预策略.
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