一种新的阿什瓦甘达配方 (ZenrootTM) 缓解了压力和焦虑症状,同时改善了情绪和睡眠质量:一个随机,双盲,安慰剂控制的临床研究
Manasvi Mahadevan1, Kumarpillai Gopukumar1, Ruchi Gupta2
1, Bengaluru Neuro Center # No. 27/5, 10th Cross, 3rd Main, Margosa Road, Malleshwaram, Bengaluru, Karnataka, 560003, India.
Advances in therapy
|August 28, 2025
概括
这项研究发现,阿什瓦甘达配方ZenrootTM (ZEN) 有效地降低了轻度至中度压力的成年人的压力,改善了他们的情绪和睡眠质量. 在为期84天的试验中,ZEN的耐受性很好,没有发现安全问题.
科学领域:
- 植物化学
- 人类生理学
- 临床研究
背景情况:
- 长期的压力与情绪障碍,焦虑,失眠和代谢问题有关.
- 阿什瓦甘达是一种已知的适应物,
- 这项研究研究了ZenrootTM (ZEN),一种含有1.5%的阿什瓦甘达配方.
研究的目的:
- 评估ZEN在管理压力,焦虑,情绪和睡眠质量的安全性和有效性.
- 评估ZEN对主观和客观压力标志物的影响.
- 为了确定ZEN在经历非慢性轻度至中度压力的人类受试者的耐受性.
主要方法:
- 一项前性,随机,双盲,安慰剂对照的临床试验进行了84天.
- 九十名参与者接受了125毫克ZEN或安慰剂.
- 主要终点是减轻压力 (感知压力量表);次要终点包括焦虑,情绪,睡眠质量和压力生物标志物 (皮质醇,sAA).
主要成果:
- ZEN显著改善了感知压力量表,贝克焦虑量表和匹兹堡睡眠质量指数的得分.
- 客观测量显示皮肤反应和心率变化有所改善.
- 没有发现血清皮质醇或唾液α氨酶的显著变化,并且ZEN被很好地容忍.
结论:
- 补充ZEN显著降低了主观和客观压力标志物.
- 这种配方改善了情绪,睡眠质量和偶尔的焦虑症状.
- 在慢性压力的人群中,ZEN 显示出良好的安全性,需要进一步研究.
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