乌帕达西尼布的安全性概况:在27000多名患者年内对类风湿关节炎,牛皮关节炎,轴性脊髓关节炎,无形皮肤炎和炎症性肠病进行描述性分析
在PubMed上查看摘要
概括
此摘要是机器生成的。这项研究评估了Janus激酶抑制剂upadacitinib在多种炎症疾病中的长期安全性. 这些发现支持其继续用于治疗慢性疾病,其安全性与之前的研究一致.
科学领域
- 免疫学
- 关节病学
- 皮肤病学
- 胃肠病学
背景情况
- 乌帕达西尼布是一种口服的,选择性的,可逆的Janus激酶抑制剂.
- 它的长期安全性在类风湿性关节炎 (RA),牛皮性关节炎 (PsA),化性脊柱炎 (AS),非放射性轴性脊柱炎 (nr-axSpA),阿托皮性皮肤炎 (AD),克罗恩病 (CD) 和性结肠炎 (UC) 中得到评估.
研究的目的
- 在患有各种慢性炎症疾病的患者中报告upadacitinib的长期安全性.
- 根据对16项临床研究的综合分析,提供最新的安全数据.
主要方法
- 来自16项研究的数据 (截止日期为2024年8月15日) 被综合到各个适应症.
- 治疗引起的不良事件 (TEAE) 被分析为每 100 个患者年 (n/100 PY) 的暴露调整的发病率.
- 有效的比较剂包括适用时的阿达利木马布和甲状腺素.
主要成果
- 这项分析包括8632名接受上达西提尼布治疗的患者,暴露时间超过27000个PY.
- 常见的TEAE包括COVID-19和上呼吸道感染;发病率因症状而异.
- 报告了严重的TEAE,TEAE导致的终止和导致死亡的TEAE,并详细介绍了特别重要的特定不良事件.
结论
- 乌帕达西尼布的长期安全性与之前的研究结果一致.
- 安全性数据支持对这些慢性疾病的长期治疗继续使用upadacitinib.
- 观察到的TEAE率的变化可能归因于人口差异和并发症.
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