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在REACH试验中,在撒哈拉以南非洲的青少年女孩和年轻女性中,每月服用达皮维林环的接受度高于每日口服预暴露预防

Barbara A Friedland1, Erica N Browne2, Sarah T Roberts2

  • 1Population Council, Center for Biomedical Research, 1230 York Ave, New York, NY, USA.

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概括

青春期女孩和年轻女性更喜欢使用达皮维林阴道环,而不是口服预暴露预防 (PrEP). 提供HIV预防方法的选择,如戒指和口服PrEP可以增加吸收率.

关键词:
可接受性青少年女孩和年轻女性非洲地区达皮维林环预防艾滋病毒预备剂

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科学领域:

  • 公共卫生
  • 预防传染病
  • 青少年的健康

背景情况:

  • 口服预暴露预防 (PrEP) 是预防艾滋病毒的一个关键工具,但其在青少年女孩和年轻女性 (AGYW) 中的应用一直不一致.
  • 达皮维林阴道环 (ring) 提供了AGYW的替代生物医学预防方法.

研究的目的:

  • 在AGYW中比较达皮维林阴道环与口服PrEP的可接受性.
  • 确定与这些艾滋病预防方法的可接受性相关的因素.

主要方法:

  • 一项随机试验 (MTN-034/REACH) 涉及南非,乌干达和津巴布韦的247名年轻妇女.
  • 参与者分别使用环和口服PrEP6个月.
  • 使用5分级来评估可接受性,评估产品特性和使用属性.

主要成果:

  • 与口服PrEP (41%) 相比,达皮维林环的整体可接受性显著提高 (65%的评分为" 5") (调整后的风险差异为24%).
  • 这两种产品的高可接受性与自己评价的良好附着性,产品外观的积极性和易用性有关.
  • 对于口服PrEP,不担心或经历副作用也与高可接受性相关.

结论:

  • 在AGYW中,达皮维林阴道环的可接受性明显高于口服PrEP.
  • 一个显著的少数参与者报告了口服PrEP的高可接受性,即使经历了戒指.
  • 提供与避孕服务相似的PrEP产品的选择对于增加这一群体的艾滋病毒预防方法至关重要.