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切除与早期肺癌细分切除,考虑切除边缘和淋巴结评估:一项回顾性研究

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切除与早期肺癌细分切除,考虑切除边缘和淋巴结评估:一项回顾性研究

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切除与早期肺癌细分切除,考虑切除边缘和淋巴结评估:一项回顾性研究

In Ha Kim¹, Han Pil Lee², Geun Dong Lee¹

¹Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

|August 28, 2025

在PubMed 上查看摘要

概括

此摘要是机器生成的。

切除和细分切除在足够的边际的情况下,在早期肺癌中显示出相似的无复发生存率 (RFS). 细分切除术提供了较好的RFS与不足的边缘,突出显示了手术技术和边缘状态在肺腺癌治疗的重要性.

关键词:

肺部癌症切除边缘分段切除术下叶膜切除切除

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科学领域:

胸部手术
外科瘤学
肺部医学

背景情况:

早期肺癌的切切除和细分切除之间的预后差异受到争议.
切除边缘状态和淋巴结 (LN) 评估是肺癌手术结果的关键因素.

研究的目的:

在临床阶段的IA1-IA2肺腺癌中,比较切除和细分切除之间的无复发存活率 (RFS).
评估切除边缘状态和LN评估对接受亚叶切除的患者RFS的影响.

主要方法:

在临床阶段的IA1-IA2肺腺癌患者中进行了1205例后期审查 (2011-2021年).
使用1:1倾向分数匹配 (PSM) 来创建可比的切除和细分切除组.
使用可靠差异估计器的Cox比例危险模型进行了无复发生存 (RFS) 的比较.

主要成果:

在PSM后,分析了636名患者 (318对). 在切除和细分切除之间没有发现显著的RFS差异 (P=0. 087).
在具有足够差距的患者中,RFS在PSM前后两组之间没有显著差异.
在没有足够边缘的患者中,分段切除显示PSM后RFS显著改善 (P=0. 046).

结论:

当达到足够的外科边缘和LN评估时,切除和细分切除在早期肺腺癌中产生可比的RFS.
在没有足够的边缘的情况下,细分切除术可能是有利的,这表明手术技术在优化结果方面发挥了作用.