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相关概念视频

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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相关实验视频

Updated: Sep 9, 2025

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

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脂蛋白E,执行功能和认知状态的差异:一个横截面研究

Ferdinand Delgado, Fang Yu, Daniel S Peterson

    Dementia and geriatric cognitive disorders
    |August 28, 2025
    PubMed
    概括

    阿波脂蛋白E4 (ApoE4) 不影响执行功能 (EF) 与跌倒的关系. 然而,EF对老年人的认知状态的影响有所不同.

    科学领域:

    • 神经科学
    • 老年学
    • 公共卫生

    背景情况:

    • 在老年人中,跌倒是主要的公共健康问题.
    • 执行功能 (EF) 损伤是已知的跌倒风险因素.
    • 在EF下降关系中,Apolipoprotein E4 (ApoE4) 的作用尚不清楚.

    研究的目的:

    • 调查ApoE4对EF和跌倒之间的关系的缓解作用.
    • 检查不同认知状态之间的这种关系:无障碍认知,轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 痴呆.

    主要方法:

    • 来自亚利桑那州老化和神经退行性疾病研究的486名参与者的横截面分析.
    • 通过复合隐性变量评估EF (Trail Making Test,Stroop干扰,数字跨度,时钟绘图,口语流性).
    • 确定ApoE基因型;用于分析落史和未来落的后勤回归.

    主要成果:

    • ApoE4并没有显著缓解EF-下降关系.
    • 在没有认知障碍和MCI的个体中,EF与跌倒史有关,但不是AD痴呆症.
    • 像帕金森的尺度元素,医疗状况和抑郁症等共变量与跌倒史有关;医疗状况和跌倒史与未来的跌倒有关.

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    Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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    Last Updated: Sep 9, 2025

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    Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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    结论:

    • ApoE4不会改变EF与跌倒之间的关联.
    • EF对跌倒的影响取决于个体的认知状态.