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Updated: Sep 9, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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Published on: May 14, 2021

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UBR4复合体的结构,一个巨大的E4连接酶,对真核蛋白质质量控制至关重要

Daniel B Grabarczyk1, Julian F Ehrmann1,2, Paul Murphy1

  • 1Research Institute of Molecular Pathology, Vienna BioCenter (VBC), Vienna, Austria.

Science (New York, N.Y.)
|August 28, 2025
PubMed
概括

研究人员揭示了UBR4 E4结合酶大复合体的结构, 这种复杂的目标是破坏蛋白质的降解, 维持细胞的健康和功能.

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