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急性周围可能是与药物相关的骨缩的危险因素
1Department of Oral Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, Florida, USA.
American journal of dentistry
|August 28, 2025
概括
患有急性周围 (PAs) 的患者患上与药物相关的骨瘤 (MRONJ) 的风险显著增加. 及时的牙科护理和口腔卫生对于MRONJ患者来说至关重要,以预防PAS.
科学领域:
- 口腔和面外科
- 牙科研究
- 药理学
背景情况:
- 与药物相关的骨 (MRONJ) 是一种与抗吸收药物相关的严重疾病.
- 急性牙周 (PAs) 是一种严重的牙感染.
- 需要进一步调查PA和MRONJ风险之间的关系.
研究的目的:
- 确定急性周围 (PAs) 和与药物相关的骨 (MRONJ) 之间的关联.
- 在急性PAS患者中评估MRONJ的风险.
主要方法:
- 美国一家医疗中心对179122名患者的病历进行了回顾性分析.
- 使用诊断码识别MRONJ和急性PAs的患者.
- 对概率比率进行统计分析,以确定PA与MRONJ之间的关联.
主要成果:
- 患有PAS的患者显示MRONJ的发病率明显较高.
- 糖尿病患者的MRONJ概率为6. 21 (P< 0. 0001),调整后OR为5. 33 (P= 0. 0001),而吸烟患者为4. 44 (P= 0. 001).
- 双酸盐使用者,尤其是阿伦德罗纳特使用者,患MRONJ风险增加.
结论:
- 口腔保健提供者必须认识到急性PAS患者的MRONJ风险增加.
- 建议加强口腔卫生和定期进行牙科检查.
- 牙病变的及时诊断和治疗对于治疗MRONJ至关重要.
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