高风险乳腺癌老年患者的死亡原因:主要原因是什么?
在PubMed上查看摘要
概括
此摘要是机器生成的。高危乳腺癌的老年人面临非癌症死亡的高风险,但化学疗法治疗不足是常见的. 仔细评估风险,益处和死亡原因对于这一群体至关重要.
科学领域
- 癌症学
- 老年医学
- 流行病学
背景情况
- 乳腺癌对老年人产生不成比例的影响,导致化学疗法治疗过度或不足.
- 现有文献对老年乳腺癌患者的癌症与非癌症死亡风险进行了不充分的量化.
- 这项研究调查高风险乳腺癌的老年人死亡原因.
研究的目的
- 分析患有高风险II和III期乳腺癌的大群老年人的死亡原因.
- 在这个人口群体中量化非癌症死亡风险.
- 在老年乳腺癌患者中识别化疗过度和不足的模式.
主要方法
- 使用BC癌症乳腺癌结果数据库进行回顾性队列研究.
- 包括在2005年至2010年间诊断出患有高风险乳腺癌 (III期或II期三阴性/HER2阳性) 的50岁及以上的患者.
- 随访直到死亡或2020年底,死亡原因通过生命统计和图表审查得到确认.
主要成果
- 较年长的患者 (70岁以上) 与较年轻的患者 (26. 9%) 相比,因非乳腺癌原因死亡的可能性显著增加.
- 心血管疾病和二次恶性瘤是主要的非癌症死亡原因.
- 老年患者的治疗不足率较高 (28. 5%),而年轻患者的治疗过度率较高 (22. 7%).
结论
- 患有高风险乳腺癌的老年人有很大的非癌症死亡风险.
- 化疗治疗不足仍然是这一群体的一个重要问题.
- 治疗决策需要全面的风险效益分析,考虑竞争的非癌症死亡风险.
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