相关实验视频
Updated: Sep 9, 2025

07:59
Molecular Entanglement and Electrospinnability of Biopolymers
Published on: September 3, 2014
14.8K
高碳甲酸粉和阿斯塔桑丁含有复合物:合成,表征和受控的输送
Guihong Fang1, Xuedi Wu2, Liang Qi3
1Carbonhydrate Lab, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; International Collaborative Research Center for the Development and Utilization of Tropical Food for Special Medical Purpose, School of Public Health,Hainan Medical University, HaiKou, 571199, China.
Food chemistry
|August 28, 2025
概括
一种新型的适应pH的高氨糖甲糖玉米粉 (CMHAS) 有效地封装了阿斯丁 (ASTA). 这种含有复合物提供了增强的稳定性和受控的释放,保护阿斯塔桑.
科学领域:
- 食品科学与技术
- 材料科学
- 生物化学
背景情况:
- 阿斯丁 (ASTA) 是一种强大的抗氧化剂,其稳定性和生物可用性有限.
- 开发有效的输送系统对于保护ASTA的特性至关重要.
- 高碳甲基玉米粉 (CMHAS) 显示出作为功能性食品成分的潜力.
研究的目的:
- 开发一种适应pH的CMHAS载体,用于阿斯丁封装.
- 描述阿斯塔克桑/CMHAS含有复合物的结构和功能性质.
- 评估封装阿斯塔桑的稳定性和受控释放行为.
主要方法:
- 在CMHAS中进行阿斯塔桑封装的共同沉方法.
- 使用膨胀度,光透度和泽塔电位的物理化学表征.
- 通过X射线衍射 (XRD) 和核磁共振 (NMR) 光谱进行结构分析.
- 使用热重力学分析 (TGA) 进行热稳定性评估.
- 在体外胃肠道模型释放研究.
主要成果:
- CMHAS表现出pH依赖的结构转变,证实了它的反应性.
- 优化的ASTA/CMHAS复合物实现了1.3mg/g的负载能力和32.11%的封装效率.
- 通过XRD检测证实了V型结晶合体的形成,结晶度为27. 4%.
- 通过核磁共振检测出阿斯塔桑在氨酸螺旋体内存在.
- 在TGA中,包含复合物的热稳定性提高了 (25. 01%的保留率).
- 在体外研究中,阿斯塔桑的释放得到控制,在125分钟内释放了45. 9%,在245分钟内释放了91. 3%.
结论:
- 响应pH的CMHAS是阿斯丁封装的有效载体.
- 开发的包含复合物增强了阿斯塔桑的热稳定性,并保护了其抗氧化活性.
- 复合物的受控释放特征改善了阿斯丁的输送和潜在的生物可用性.
相关概念视频
Chemistry of Carbohydrates
75.2K
Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...
75.2K
Oligosaccharide Assembly
3.0K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
3.0K
Preparation of Carboxylic Acids: Overview
2.7K
There are various methods for the preparation of carboxylic acids. For example, oxidation of primary alcohols or aldehydes using strong oxidizing agents results in a carboxylic acid. Aldehydes can also be oxidized in the presence of mild oxidizing agents.
2.7K
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
3.6K
Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
3.6K

