感知到的压力和社会经济地位不同地调节了孕激素和皮质醇对社会评估的冷压力任务的反应性
Eleanor H Goulden1, Charleen J Gust2, Angela D Bryan1
1University of Colorado Boulder Department of Psychology and Neuroscience, Muenzinger D244, 345 UCB, Boulder, CO 80309-0345, USA.
Psychoneuroendocrinology
|August 28, 2025
概括
孕激素会影响皮质醇应激反应,但这种影响因社会经济地位 (SES) 和感知压力而有所不同. 较低的SES和较高的感知压力改变了孕激素对女性皮质醇反应性的影响.
科学领域:
- 内分泌学
- 心理神经内分泌学
- 压力生理学
背景情况:
- 关于孕激素在生理应激反应中的作用存在不一致的发现.
- 心理社会压力,包括压力暴露 (例如,低社会经济地位[SES]) 和感知压力,可能会调节孕激素的影响.
- 之前对先前存在的压力水平如何影响皮质醇对急性压力的反应也产生了不同的结果.
研究的目的:
- 研究孕激素,主观SES和感知压力之间的相互作用,以预测皮质醇对实验室心理社会压力因素的反应.
- 澄清孕激素对急性应激反应的影响的异质发现.
主要方法:
- 66名大学生接受了社会评估的冷压力测试.
- 唾液激素 (皮质醇) 在任务前,任务后立即测量,并在任务后20分钟测量.
- 评估了主观SES和感知压力 (感知压力量表 (PSS) 评分).
主要成果:
- 孕激素对皮质醇反应的主要影响是:低水平的孕激素与皮质醇反应的减弱有关,而高水平的孕激素则预测皮质醇的典型升高.
- 社会经济地位 (SES) 和PSS得分调节了孕激素与皮质醇的关系.
- 具体而言,在孕激素高的女性中,较低的SES与皮质醇反应相对应,而较高的感知压力与皮质醇反应相对应.
结论:
- 在女性中,主观SES和感知压力显著调节孕激素水平与急性压力反应的关系.
- 了解这些调节效应对于解释与孕激素和压力相关的健康结果的个体差异至关重要.
- 这项研究有助于理解月经周期变化对心理健康和基于孕激素的避孕药的影响.
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