更年期和动脉样性心血管疾病的风险:来自英国女性生物库队列的见解
1Department of Epidemiology and Public Health, Foch Hospital, Suresnes, 92150, France.
Maturitas
|August 28, 2025
概括
更年期独立增加了动脉样硬化心血管疾病 (ASCVD) 的风险,特别是在60岁以下的女性中. 这凸显了中年期有针对性的预防策略的必要性.
科学领域:
- 心血管流行病学
- 生殖内分泌学
- 公共卫生
背景情况:
- 更年期会引发荷尔蒙和代谢变化,可能会增加动脉样硬化心血管疾病 (ASCVD) 的风险.
- 更年期对ASCVD风险的具体贡献,独立于衰老,仍然是正在进行的调查.
- 这项研究旨在明确更年期与ASCVD风险之间的联系.
研究的目的:
- 研究更年期与动脉样硬化心血管疾病 (ASCVD) 风险之间的独立关联.
- 量化因更年期而增加的ASCVD风险.
- 确定更年期中 ASCVD 风险影响最大的特定年龄组.
主要方法:
- 分析了222,007名英国女性的数据,
- 使用聚合队列方程计算ASCVD风险,高风险定义为10年风险≥7.5%.
- 使用了根据年龄,社会经济,生活方式,代谢和临床因素调整的多变量回归模型.
主要成果:
- 与更年期前妇女 (0. 81%) 相比,更年期后妇女的ASCVD风险估计显著增加 (3. 75%).
- 在绝经后的妇女中,高ASCVD风险的患病率明显高于绝经前的妇女 (9. 65%).
- 更年期独立地与ASCVD风险增加0. 56%,高ASCVD风险的可能性增加18%,特别是在60岁以下的女性中.
结论:
- 更年期是增加动脉样硬化心血管疾病 (ASCVD) 风险的独立危险因素,特别是在60岁以下的女性中.
- 这些发现强调了将更年期状态纳入中年妇女心血管风险评估的重要性.
- 对于经历更年期的妇女,应考虑针对性心血管预防策略.
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