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Updated: Sep 9, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

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复合异性DMC1变体因复制蛋白A的缺陷而导致非阻塞性亚精

Yan Wang1, Renxue Wang1, Ziyou Bao1

  • 1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, 250012, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, China.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, 250012, China.; Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, China.; Shandong Key Laboratory of Reproductive Research and Birth Defect Prevention (Under Construction), Jinan, Shandong, 250012, China.; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, 250012, China.

Reproductive biomedicine online
|August 28, 2025
PubMed
概括

一种新型的异构体DMC1变体通过破坏半球变异导致非阻塞性亚精. 这导致缺陷的DNA修复和同源配对,在Dmc1淘汰小鼠中得到证实.

关键词:
复合异构型变种一个DMC男性不孕症在RPA积累精子发生停止

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