对内血管操作者的辐射诱导DNA损伤和癌症风险进行系统审查
Emma-Lena Maris1, Jurre Klaassen1, Constantijn E V B Hazenberg1
1Department of Vascular Surgery, Utrecht Medical Centre Utrecht, Utrecht, the Netherlands.
Journal of vascular surgery
|August 28, 2025
概括
在光学指导过程中,内血管操作人员因职业辐射暴露而面临更高的DNA损伤和癌症风险. 加强安全措施和宣传对于保护这些专业人士至关重要.
科学领域:
- 医学成像和辐射瘤学
- 职业健康和安全
- 遗传学和分子生物学
背景情况:
- 血管内干预越来越多地取代了开放式手术,导致人们越来越依赖光镜.
- 光学使用电离辐射,给医疗保健专业人员带来职业辐射暴露的风险.
- 血管内科医生是最容易受到辐射的医院工作人员之一, 对辐射引起的DNA损伤和癌症风险的研究有限.
研究的目的:
- 对职业辐射暴露及其对内血管操作者的影响进行系统审查.
- 评估光学诱导辐射对DNA损伤和癌症风险的贡献.
主要方法:
- 从2000年到2025年4月,在PubMed和EMBASE上进行了系统的文献搜索,遵循PRISMA指南.
- 包括的研究检查了因职业辐射暴露而进行内血管手术的操作人员的DNA损伤或癌症发生情况.
- 研究根据主要结果进行分类:癌症和DNA损伤,有偏差评估的风险.
主要成果:
- 25项研究表明,职业辐射会导致早期和慢性DNA损伤,包括双链断裂和染色体异常.
- 这种DNA损伤被假定会导致基因组不稳定和致癌.
- 在内血管操作者中观察到癌症的风险增加,特别是对辐射敏感的癌症 (白血病,甲状腺) 和未受保护的区域 (皮肤,大脑).
结论:
- 内血管操作人员面临光镜检查导致的慢性健康影响,包括慢性DNA损伤和致癌的风险.
- 尤其是在脆弱的部位和不受保护的身体部位面临风险.
- 需要加强内血管专家的辐射安全措施,意识和预防策略.
更多相关视频
11:27Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging
Published on: April 4, 2013
12.6K
09:32Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging
Published on: December 9, 2021
3.1K
相关概念视频
02:59Biological Effects of Radiation
15.9K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.9K
01:22Aneurysm IV: Nursing Management
20
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
20
01:38Nucleotide Excision Repair
3.8K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.8K