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在T-ALL中探索Dendrobium officinale多糖的潜在向治疗,结合网络药理学,生物信息学和实验验证

Bian Tierong¹, Xing Yibo², Wan Runlan³

¹Medical Experiment Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

International journal of biological macromolecules

|August 28, 2025

概括

丁 officinale 多糖 (DOP) 对T细胞急性淋巴细胞白血病 (T-ALL) 有抗瘤作用. 网络药理学和实验显示DOP向关键的癌症途径,诱导T-ALL细胞的细胞亡和细胞循环停止.

科学领域:

药理学
癌症学
生物信息学

背景情况:

丹 officinale 多糖 (DOP) 具有抗瘤的特性.
对T细胞急性淋巴细胞白血病 (T-ALL) 的DOP治疗潜力尚不清楚.

研究的目的:

研究T-ALL中DOP的治疗目标和机制.
通过实验方法验证DOP对T-ALL的抗瘤作用.

主要方法:

公共数据库和RNA测序数据的网络药理和生物信息分析.
蛋白与蛋白相互作用网络的构建和枢纽目标的识别.
基因本体学 (GO) 和KEGG通路分析,分子对接和Jurkat细胞的实验验证.

主要成果:

确定了DOP和T-ALL共享的13个共同目标,包括CARD11和CCND1等关键枢纽目标.
发现这些点参与通过癌症,细胞循环,PI3K-AKT和NF-κB信号通路调节细胞亡和增殖.
实验验证证DOP在S阶段诱导T-ALL细胞周期停止,增强细胞亡,并改变13个向基因的表达.

结论:

通过向多种与癌症相关的途径,DOP对T-ALL具有显著的抗瘤作用.
这项研究阐明了DOP在T-ALL治疗中有效性的分子机制.
作为T-ALL的治疗药物,DOP有望向多种细胞过程.

关键词:

生物信息学丹德罗 (Dendrobium officinale) 多糖分子机制网络药理学 T细胞急性淋巴细胞白血病 (T-ALL)

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