在成年人中与呼吸道同胞病毒中和抗体标位相关的因素
Kensuke Shoji1, Masaki Yamada2, Michi Hisano3
1Center for Postgraduate Education and Training, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan; Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
概括
呼吸道同胞病毒 (RSV) 中和抗体标位随年龄变化而变化,在30多岁时下降. 较高的标位与慢性疾病和生小孩有关,这表明暴露会影响免疫力.
科学领域:
- 免疫学
- 病毒学
- 公共卫生
背景情况:
- 呼吸道同胞体病毒 (RSV) 导致严重的儿童疾病.
- 关于成人RSV血清流行率和中和抗体标位的数据有限.
- 成年人接种疫苗的策略正在进步,需要更好地了解成年人的免疫力.
研究的目的:
- 在成年人中测量RSV中和抗体标位.
- 探索与成人RSV抗体水平相关的因素.
- 分析与年龄相关的RSV免疫趋势.
主要方法:
- 在日本对1226名医疗保健和非医疗保健工作者进行的横截面研究.
- 从血液样本中分析RSV中和抗体标位.
- 用于分析的多变量修改Poisson回归和受限制的立方线模型.
主要成果:
- 4. 5% 的参与者为血清阴性; 63. 5% 的参与者为血清阴性.
- 抗体标位在20年代初达到峰值,在30年代下降,随后随年龄变化而变化.
- 与30至39岁,慢性疾病和有9岁以下儿童的家庭有关.
结论:
- RSV抗体标位呈现年龄依赖的模式,在30多岁时水平较低.
- 慢性疾病和幼儿暴露与较高的RSV抗体度相关.
- 暴露史在成年人对RSV免疫力的形成中起着至关重要的作用.
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