从弹性体阴道环中持续释放乳酸的前期药物策略
Yahya H Dallal Bashi1, Xinyu Zhao2, Clare F McCoy2
1College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.
International journal of pharmaceutics
|August 28, 2025
概括
可以将乳酸前药物DL添加到环中,以提供乳酸用于避孕和预防感染. 这项创新克服了与传统乳酸输送系统的材料不兼容问题.
科学领域:
- 生物材料科学
- 生殖健康
- 微生物学
背景情况:
- 乳酸对阴道健康至关重要,
- 失生导致乳酸减少,pH值增加,细菌性阴道炎和性传播感染的风险增加.
- 由于材料不兼容,目前的乳酸输送方法面临局限性,特别是在阴环制造方面.
研究的目的:
- 开发一种将乳酸融入阴环的方法,以持续释放.
- 评估释放的乳酸在抑制精子运动,病毒复制 (HIV-1,HSV-2) 和细菌生长 (Gardnerella vaginalis) 的有效性.
主要方法:
- DL- 乳酸是一种循环乳酸,被纳入医用级弹性阴道环中.
- 在实验室中研究了从环中释放到水中的DL-乳化物.
- 已证实释放的DL-乳化物到乳酸的水解.
- 释放的乳酸的生物活性与精子,HIV-1,HSV-2,Gardnerella阴道菌和乳酸菌进行了评估.
主要成果:
- DL- 乳化物成功地融入并从环中释放出来.
- 释放的DL-乳酸在水环境中迅速化为乳酸.
- 释放的乳酸显示抑制了精子运动,HIV-1,HSV-2和阴道菌.
- 释放的乳酸并没有抑制乳酸菌的生长.
结论:
- DL-乳酸作为一种有效的乳酸前药物,用于从环中持续释放.
- 这种方法克服了材料兼容性问题,使下一代多功能避孕环的开发成为可能.
- 释放的乳酸有可能用于非荷尔蒙避孕和预防性传播感染和细菌性阴道炎.
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