对有机杀虫剂的急性,长期和慢性暴露对体外神经元活动和网络发育产生不同影响
Lennart V J van Melis1, Teije Bak1, Anneloes M Peerdeman1
1Neurotoxicology Research Group, Division of Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, Utrecht NL-3508 TD, the Netherlands.
Neurotoxicology
|August 28, 2025
概括
像DDT和迪尔德林这样的有机杀虫剂会破坏神经元活动和网络发展. 急性暴露会导致过度兴奋,而长期暴露会抑制活性,即使在低度,非细胞毒性.
科学领域:
- 神经科学
- 环境毒理学
- 发育生物学
背景情况:
- 有机杀虫剂暴露与神经发育和神经退行性疾病有关.
- 这些化合物会导致神经系统过度活跃,影响平衡,神经细胞增长和神经递质水平.
- 在之前的研究中观察到的性别特异性影响需要在两种性别中进行研究.
研究的目的:
- 研究急性,长期和慢性杀虫剂对神经网络活动和发育的影响.
- 在性别分离的老鼠原皮质培养物中检查这些效应.
- 评估DDT,DDE,内硫,迪尔德林和林丹的影响.
主要方法:
- 使用微电极阵列 (MEA) 记录来监测神经元活动.
- 在急性 (30分钟),长时间 (长达48小时) 和慢性 (21天) 期间暴露于大鼠的皮质原始培养物.
- 测试的度从低微分量到高微分量,包括非细胞毒性剂量.
主要成果:
- 对所有测试的有机剂的急性暴露导致神经元过度激发,有时度≤1μM.
- 长期暴露于DDT,DDE,内硫和迪尔德林抑制了神经元活动;林丹没有明显的影响.
- 在高微分子度下,慢性暴露抑制了神经网络的发展;大多数效应非细胞毒性.
结论:
- 有机杀虫剂对神经元活动和神经网络发育产生不同的影响,这取决于暴露时间.
- 在与人类接触水平相关的度下发生DDT,内硫,迪尔德林和林丹的急性作用.
- 由于观察到的神经毒性作用,对人体接触有机杀虫剂的进一步监测至关重要.
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