在没有痴呆症的帕金森病患者中使用规范模型的脑结构偏差
Zhizheng Zhuo1, Li Chai1, Yutong Bai2
1From the Department of Radiology (Z.Z., L.C., T.H., J.S., Y.L., Y.D.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
AJNR. American journal of neuroradiology
|August 28, 2025
概括
没有痴呆症的帕金森病 (PD) 呈现异质皮质变化,近一半的区域偏离. 皮质厚度较薄的PD可能与更严重的步态结相关.
科学领域:
- 神经科学
- 神经学
- 放射学
背景情况:
- 没有痴呆症的帕金森病 (PD) 诊断呈现出不一致的皮质改变结果.
- 了解这些变化对于早期诊断和症状管理至关重要.
研究的目的:
- 在没有痴呆症的PD患者中调查皮质结构偏差.
- 探索皮质变化与PD运动/非运动症状之间的关系.
主要方法:
- 在225名PD患者中使用寿命大脑图来获得个性化的百分位数.
- 将PD患者的数据与451名健康对照人进行比较,并进行皮质厚度与症状之间的相关性分析.
主要成果:
- 在PD患者中,近一半 (44. 11%) 的皮层区域显示出负偏差,其中下皮层受影响最大.
- 患者呈现灰质量的负偏差和脑脊液 (CSF) 量的正偏差,没有显著的白质量变化.
- 皮层厚度与步行结程度相关,
结论:
- 没有痴呆症的皮质变化是异质的,其特征是灰质的广泛负偏差.
- 结构变化包括灰质减少,脑脊髓液体体积增加和白质体积保存.
- 在PD患者中,皮质厚度降低与更严重的步行结有关.
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