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Updated: May 10, 2026

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在不可切割的胰腺癌中检测循环瘤DNA中的KRAS突变预测系统

Hiroshi Shimizu1, Rei Suzuki2, Hiroyuki Asama1

  • 1Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Anticancer research
|August 28, 2025
PubMed
概括

一个新的模型预测了使用肝转移等临床因素检测不可切除的胰腺癌 (PC) 的KRAS突变. 该工具有助于选择患者进行循环瘤DNA (ctDNA) 液体活检,改善个性化治疗策略.

关键词:
美国国家安全局胰腺癌综合基因组分析液体活检

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...