在口腔状细胞癌中化Yes相关蛋白 (YAP) (Ser 127) 表达的意义
在PubMed上查看摘要
概括
此摘要是机器生成的。在口腔状细胞癌 (OSCC) 中对化YAP (pYAP) 的研究显示了低细胞质pYAP表达. 高的pYAP与上皮转化为介质细胞转化 (EMT) 相相关,可能表明具有侵略性的OSCC.
科学领域
- 癌症学
- 分子生物学
- 细胞信号传输
背景情况
- 河马信号通路,包括哺乳动物无菌20样激酶1/2,大型瘤抑制剂1/2和Yes相关蛋白1 (YAP1),在细胞调节中起着至关重要的作用.
- 这种途径的失调与各种癌症有关,包括口腔状细胞癌 (OSCC).
研究的目的
- 在口腔上皮质异位症 (OED),现场癌症 (CIS) 和OSCC中研究化YAP (pYAP,Ser 127) 的表达.
- 在OSCC中确定pYAP表达与临床病理特征,分化和上皮转移 (EMT) 之间的相关性.
主要方法
- 在OED (n=7),CIS (n=14) 和OSCC (n=109) 患者的组织样本中分析pYAP蛋白表达.
- 评估pYAP水平与瘤分化,E-cadherin,vimentin,laminin 5和蛋白质阿尔金因甲基转移酶1的表达之间的相关性.
主要成果
- 在OED,CIS和OSCC组织中,细胞质pYAP表达通常较低.
- 与差异化OSCC相比,在良好到中度差异化的OSCC中,低pYAP表达更为频繁.
- 高pYAP表达与EMT的特征显著相关,包括降低E-cadherin和增加维门丁和拉米宁5 (p< 0. 0001).
- 增加的pYAP水平与增加的蛋白质阿基因甲基转移酶1表达相关 (p< 0. 0007).
结论
- 增加的pYAP表达可能是侵略性OSCC的预后指标.
- 高pYAP与EMT的关联表明它在OSCC的侵入性进展中的作用.
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