在治疗性尿路透镜治疗上道泌尿道癌后的肠道复发:元分析
Francesco Di Bello1,2, Andrea Gallioli1, Donato Cannoletta1,3
1Department of Urology, Fundació Puigvert, Barcelona, Spain.
BJU international
|August 28, 2025
概括
激光切除的尿路透镜 (URS) 对肠内复发 (IVR) 率的影响微不足道,并且与上道泌尿道癌 (UTUC) 的彻底瘤切除术 (RNU) 相比,并没有显著改变整体存活率. 这些发现表明URS是UTUC患者的安全选择.
科学领域:
- 尿道病学
- 癌症学
- 外科创新
背景情况:
- 治疗上部泌尿道癌 (UTUC) 往往需要进行激进性瘤切除术 (RNU),但寻求更少的侵入性选择.
- 需要进一步阐明激光切除尿管镜术 (URS) 的瘤结果.
研究的目的:
- 在UTUC患者中评估激光切除的URS的瘤安全性.
- 评估对内复发率,RNU与治疗比率和整体存活率的影响.
主要方法:
- 24项涉及1904名患者的系统审查和综合分析.
- 采用了PRISMA指导方针,对术后灌注进行亚组分析,并对URS与RNU进行比较.
主要成果:
- 总体IVR率为23. 7%. 综合分析显示IVR (0. 33),RNU与治疗比率 (0. 23) 和OS (0. 62) 的效果大小.
- 与RNU相比,URS在IVR (ES 1.14) 或OS (ES 1.43) 中没有显著的差异.
- 在URS小组中,术后灌注与IVR (ES 0. 38) 和RNU- to- treat比率 (ES 0. 25) 的降低有关.
结论:
- 激光切除的URS对UTUC的IVR率的影响微不足道.
- 在比较URS和RNU时,没有观察到IVR或OS的显著差异.
- 在不影响瘤结果的情况下,可以安全地使用URS进行UTUC管理.
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