根据病理类型的伦瓦替尼治疗的有效性:现实世界的回顾性研究
Mioko Matsuo1, Mamoru Ito2, Kenji Tsuchihashi2
1Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; matsuo.mioko.202@m.kyushu-u.ac.jp.
In vivo (Athens, Greece)
|August 28, 2025
概括
在放射性 (RAI) 治疗不可行的情况下,伦瓦提尼布对耐火分化甲状腺癌 (DTC) 是有前途的. 实验数据表明,在没有接受RAI的DTC患者中,伦瓦替尼可能改善无进展生存率.
科学领域:
- 癌症学
- 内分泌学
- 药理学
背景情况:
- 耐受性分化甲状腺癌 (DTC) 和形甲状腺癌 (ATC) 具有显著的治疗挑战和不良预后.
- 包括伦瓦提尼布在内的分子向药物可以改善患者的治疗结果.
- 有限的现实世界数据显示了lenvatinib在这些患者群体中的有效性.
研究的目的:
- 在耐火性甲状腺癌患者中评估伦瓦替尼的实际有效性.
- 为了比较用lenvatinib治疗的患者的整体存活率和无进展存活率.
- 研究先前放射性 (RAI) 治疗对DTC中伦瓦替尼的疗效的影响.
主要方法:
- 在48名用lenvatinib治疗的甲状腺癌患者的回顾性分析.
- 卡普兰-梅尔分析以比较整体存活率和无进展存活率.
- 进行小组分析,比较之前接受过RAI治疗的患者和没有接受过RAI治疗的患者.
主要成果:
- 无进展生存时间的中位数因组织学而异:乳头细胞生存时间为30个月,卵泡细胞生存时间为18个月,ATC生存时间为4个月.
- 在差异化甲状腺癌 (DTC) 患者中,以前有RAI的中位数无进展生存期为19个月,没有RAI的中位数为46个月 (p=0. 243).
- 伦瓦替尼在不同类型的甲状腺癌中表现出不同的疗效.
结论:
- 伦瓦替尼可能是差异化甲状腺癌 (DTC) 患者的一种有价值的治疗选择,特别是当放射性 (RAI) 治疗不可行时.
- 这项研究强调需要进一步实践研究伦瓦替尼在治疗耐火性甲状腺癌中的作用.
- 在没有接受RAI治疗的DTC患者中,实验数据表明lenvatinib的潜在益处.
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