治疗头癌的长期结果和混合反应
Yoh-Ichiro Iwasa1, Ryosuke Kitoh2, Yoh Yokota2
1Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto, Japan iwasa@shinshu-u.ac.jp.
In vivo (Athens, Greece)
|August 28, 2025
概括
在复发性/ 转移性头癌 (RM- HNC) 患者中,尼沃卢马布显示有希望的长期存活率,特别是在鼻癌 (NPC) 中. 混合反应 (MR) 表明RM-HNC的预后更好.
科学领域:
- 癌症学
- 免疫疗法
- 头癌研究
背景情况:
- 复发性/转移性头癌 (RM-HNC) 存在重大治疗挑战.
- 在RM-HNC中对长期nivolumab疗效的实际数据有限.
研究的目的:
- 在现实临床环境中评估使用nivolumab治疗的RM-HNC患者的长期结果.
- 确定对尼沃卢马布治疗有良好反应的患者子组.
主要方法:
- 在2017年至2024年期间接受尼沃卢马布治疗的53名RM-HNC患者的回顾性分析.
- 评估整体存活率 (OS),无进展存活率 (PFS),反应率和与免疫相关的不良事件 (irAEs).
主要成果:
- 平均生存期为18. 1个月,4年生存率为23. 3%.
- 在17%的患者中观察到混合反应 (MR),与明显改善的生存状况相关 (p=0. 007).
- 在超出 CheckMate 141 标准的患者中,Nivolumab 显示出有效性,特别是在鼻癌 (NPC) 中,平均生存期为 44. 0 个月.
结论:
- 在现实世界RM-HNC队列中,Nivolumab具有持久的长期疗效.
- 鼻癌 (NPC) 患者和不符合CheckMate 141标准的患者可能会显著受益.
- 混合反应 (MR) 是改善RM- HNC生存的新预后指标.
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