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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: May 8, 2026

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
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用Granzyme B激活的近红外II比度光纳米探针用于早期检测瘤对免疫治疗的反应

Lei Ding1,2,3, Xiaolong Zhang4,5, Peiyuan Wang3,6

  • 1School of Rare Earths, University of Science and Technology of China, Hefei, P. R. China.

Nature communications
|August 28, 2025
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概括

一种新奇的稀土纳米探测器可进行非侵入性实时成像,预测癌症免疫治疗反应. 这种工具通过可视化深层组织T细胞激活来帮助精确医学.

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科学领域:

  • 生物医学工程
  • 纳米技术
  • 癌症研究

背景情况:

  • 对抗瘤免疫反应的早期检测对于精确的癌症免疫治疗至关重要.
  • 目前的光学成像探测器在体内应用的成像深度,通道和量化方面存在局限性.

研究的目的:

  • 开发一种基于稀土的近红外II (NIR-II) 光比纳米探测器 (DCGA) 用于体内可视化酶B (GzmB) 活性.
  • 通过GzmB活动监测,实现免疫疗法的实时,精确和非侵入性预测.

主要方法:

  • 开发用于NIR-II双发射比度检测的Nd/Er辅助DCGA纳米探针.
  • 在体内进行比率成像,以将GzmB活性与细胞毒性T细胞反应和瘤生长相关联.
  • 在Hepa 1- 6和患者衍生的异种移植瘤模型中进行验证.

主要成果:

  • DCGA纳米探测器提供自我校准的信号,克服探测器分布和干扰问题.
  • 探针可视化的GzmB活动与T细胞反应和瘤进展有很强的相关性.
  • 在临床前模型中,该探针有效区分免疫疗法响应者与不响应者.

结论:

  • DCGA纳米探针可在深层组织中进行T细胞激活的动态,实时,非侵入性分子成像.
  • 这项技术支持瘤免疫治疗研究,精准医学和个性化诊断.
  • 开发的探针解决了当前用于免疫治疗监测的成像工具的关键局限性.