通过结合原生扩张和粘附控制的神经元迁移进行皮质折叠
Seung Hee Chun1, Da Eun Yoon2, D Santiago Diaz Almeida1
1Department of Molecules - Signaling - Development, Max Planck Institute for Biological Intelligence, Martinsried, Germany.
Nature communications
|August 28, 2025
概括
在小鼠中,基因操纵Flrt1/3粘附分子和祖细胞扩张显著增强大脑皮层折叠. 这些发现揭示了驱动皮质化的关键发育机制.
科学领域:
- 发展神经科学
- 遗传学
- 计算生物学
背景情况:
- 大脑皮层折叠对哺乳动物大脑功能至关重要,但其发育机制仍然不完全理解.
- 之前的研究表明,Flrt1/3粘附分子的遗传删除通过影响神经元迁移来诱导小鼠的皮质折叠.
- 前者扩张在调节Flrt1/3介导的皮质折叠中的作用尚未被研究.
研究的目的:
- 研究原生扩张如何与Flrt1/3基因缺失相互作用以影响大脑皮层折叠.
- 确定中间和顶端前代扩张在调节旋转模式中的特定作用.
主要方法:
- 使用了Flrt1/3和Cep83 (中间祖先) 或Fgf10 (尖端祖先) 的综合遗传缺失的小鼠模型.
- 分析了导致的皮层折叠模式,神经元迁移和祖先群体.
- 使用计算建模来模拟和理解观察到的折叠背后的生物物理机制.
主要成果:
- 结合Flrt1/3删除和Cep83删除 (中间原体扩张) 导致硫形成的增强.
- 结合Flrt1/3删除和Fgf10删除 (尖端前代扩张) 导致形形成的增强.
- 计算模型支持细胞粘附,密度和迁移在促进化中的作用.
结论:
- 主体扩张显著调节Frt1/3依赖的皮质折叠.
- 扩张的原始体类型 (中间与尖端) 影响了特定的折叠模式 (与旋转).
- 粘合性质,细胞密度和神经元迁移是皮层旋转的关键,相互作用的因素.
相关概念视频
01:30Neurulation
42.6K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.6K
01:16Cell Motility through Blebbing
2.0K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
2.0K
01:19Cell Migration
5.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
5.1K
01:32Cytoskeletal Coordination in Cell Migration
4.9K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.9K
01:56Gastrulation
58.5K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
58.5K