胚胎细胞周期早期温度缩放的机制起源
Jan Rombouts1,2,3, Franco Tavella4, Alexandra Vandervelde1
1Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat, 49, Leuven, Belgium.
Nature communications
|August 28, 2025
概括
温度对外热体生理有显著影响,影响胚胎细胞周期等过程. 这项研究揭示了ectotherm细胞周期中恒定的温度缩放,由酶动力学的计算模型解释.
科学领域:
- 发育生物学
- 外热生理学
- 生物化学
- 细胞循环调节
背景情况:
- 温度对生理和生态过程有很大影响,特别是在热体生物中.
- 复杂的生理速率经常表现出类似阿雷尼乌斯的缩放,但生物化学基础尚未完全理解.
- 对于预测生态对气候变化的反应至关重要.
研究的目的:
- 在六种外热物种中研究早期胚胎细胞周期的温度缩放.
- 阐明观察到的依赖温度的细胞循环动力学的生化机制.
- 探索温度敏感性如何影响热极端的生物过程.
主要方法:
- 检查了各种外热物种 (例如,Xenopus,Danio rerio,Caenorhabditis,Drosophila) 的胚胎细胞周期的温度缩放.
- 使用计算建模模拟细胞循环动力学和酶动力学在不同温度下.
- 使用了Xenopus蛋提取物和细胞循环调节物的体外测试数据.
主要成果:
- 在胚胎细胞周期进展过程中观察到的一致的明显激活能量 (75 ± 7 kJ/mol),相当于20°C时的Q10.
- 计算模型表明细胞周期组件的双相缩放和酶的不匹配激活能解释了近似的阿雷尼乌斯行为.
- 实验数据支持提出的机制,将酶动力学与观察到的温度敏感性联系起来.
结论:
- 这项研究提供了对生态热体胚胎发育温度敏感性的机理性见解.
- 两相缩放和酶动力不匹配是推动细胞周期温度反应的关键因素.
- 了解这些机制对于预测热极限下生物过程失效至关重要.
更多相关视频
相关概念视频
Cells Coordinate Growth and Proliferation
4.6K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.6K
Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
Molecular Factors Affecting Cell Division
3.3K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.3K
Cleavage and Blastulation
45.7K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
45.7K
The Cell Cycle Control System
3.4K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
3.4K
Cellular Differentiation
3.2K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
3.2K


