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Updated: Sep 9, 2025

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
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免疫检查点抑制剂对HIV储存物的影响与前病毒序列有关,但与整合部位无关

Vincent Guiraud1, Antoine Fauchois2, Cathia Soulie2

  • 1Sorbonne University, INSERM, Pierre Louis Institute of Epidemiology and Public Health, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Laboratoire de Virologie, Paris, 75013, France. vincent.guiraud@aphp.fr.

Scientific reports
|August 28, 2025
PubMed
概括

针对PD-1,PDL-1和CTLA-4的免疫检查点抑制剂可能会改变HIV前病毒DNA. 虽然ICI并没有改变HIV的总DNA,但影响了前病毒序列,这表明它可能对HIV的储存产生影响.

关键词:
在 CTLA-4治愈艾滋病毒整合地点美国政府美国冲击并杀死病毒储存库

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