老年人视网膜层厚度与大脑体积和皮质厚度的相关性
Ji Won Han1,2, Hyeong Min Kim3, Min Jeong Kwon4
1Department of Neuropsychiatry, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.
Scientific reports
|August 28, 2025
概括
在老年人中,黄斑视网膜神经纤维层 (RNFL) 厚度与大脑结构的联系较弱. 这些初步发现表明可能与认知功能有关,但需要进一步研究以验证生物标志物.
科学领域:
- 神经科学
- 眼科 眼科
- 放射学
背景情况:
- 老化的大脑经历结构变化, 寻求非侵入性生物标志物来监测神经退行过程.
- 视网膜神经纤维层 (RNFL) 厚度是神经健康的潜在指标.
研究的目的:
- 在没有痴呆症的老年人中探索斑点RNFL厚度和大脑结构 (灰质体积和皮质厚度) 之间的关联.
- 研究斑点RNFL厚度作为早期神经退行变化的非侵入性生物标志物的潜力.
主要方法:
- 166名居住在社区的老年人 (> 65岁) 没有痴呆或眼部病理,接受了3D T1MRI和光谱域光学连贯性断层扫描以检测斑点RNFL厚度.
- 基于Voxel的形态测量和Pearson的相关性被用来分析RNFL厚度和大脑指标之间的关联,根据年龄和性别进行调整.
主要成果:
- 未经纠正的相关性表明RNFL外部厚度和灰质体积在下皮,上额皮和下皮之间存在关联.
- 总的RNFL厚度与右下皮相关,而RNFL厚度与特定大脑区域的皮层厚度存在弱相关性.
- 所有观察到的关联在多次比较后失去了统计意义,这表明统计证据有限.
结论:
- 初步发现表明黄斑RNFL厚度与与感官处理和认知相关的区域的大脑结构变化之间存在潜在的关系.
- 这些关联的统计证据有限,需要进一步的纵向研究.
- 斑点RNFL厚度可能作为神经退行过程的非侵入性生物标志物,需要进一步调查.
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