对自闭症的补充,替代和整合医学:一个总体审查和在线平台
Corentin J Gosling1,2,3, Laure Boisseleau4, Marco Solmi5,6,7,8,9
1DysCo Laboratory, Paris Nanterre University, Nanterre, France. corentin.gosling@parisnanterre.fr.
Nature human behaviour
|August 28, 2025
概括
补充,替代和整合性医学 (CAIM) 在自闭症中很常见,但缺乏其有效性的证据. 这项综合性审查没有发现CAIM对自闭症患者有好处的高质量证据,强调需要更多的安全研究.
科学领域:
- 神经发育障碍
- 综合医学
- 基于证据的实践
背景情况:
- 补充,替代和整合医学 (CAIM) 被自闭症谱系障碍 (ASD) 患者广泛使用,高达90%的人报告一生使用.
- 支持CAIM干预治疗自闭症症状的科学证据仍然不确定,需要严格评估.
- 在了解CAIM对整个生命周期的影响和安全性方面存在重大差距.
研究的目的:
- 进行元分析的综合审查,以评估CAIM对自闭症的影响的证据.
- 评估自闭症中CAIM干预措施的方法质量和证据确定性.
- 开发一个可访问的网络平台,以传播关于自闭症的CAIM发现.
主要方法:
- 进行了系统性审查和元分析的综合审查,搜索了5个数据库,截至2023年12月31日.
- 符合条件的元分析使用一致的统计方法进行了重新估计,通过AMSTAR-2评估质量,通过GRADE评估证据确定性.
- 总共有53个元分析报告被确定,导致对自闭症的19个CAIM进行了248次元分析.
主要成果:
- 没有高质量的证据支持CAIM对自闭症谱系障碍的核心或相关症状的有效性.
- 虽然一些CAIM显示出有希望的结果,但支持证据的质量始终很低.
- 对自闭症的CAIM干预措施的安全性很少被评估,这表明未来研究的关键领域.
结论:
- 目前的证据不支持使用任何CAIM治疗自闭症症状.
- 对于有希望的CAIM干预措施的证据质量不佳,需要谨慎解释和进一步调查.
- 一个交互式的网络平台 (https://ebiact-database.com) 已开发出来,以帮助基于证据的关于自闭症的CAIM决策.
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