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多巴胺与上腺素治疗新生儿败血症:一个开放的,随机的受控试验
Gurarsh Singh1, Vikram Bhaskar2, Prerna Batra1
1Department of Pediatrics, University College of Medical Sciences, Delhi, India.
概括
在新生儿败血性休克中,多巴胺和上腺素在60分钟内逆转休克的效果相似. 这两种药物在新生儿中表现出相似的结果.
科学领域:
- 新生儿重症监护
- 儿童重症监护
- 药理学
背景情况:
- 这是新生儿死亡的主要原因.
- 多巴胺和上腺素是抗流体新生儿败血症的主要治疗方法.
- 目前的指导方针对于首选的第一线代理商缺乏共识.
研究的目的:
- 为了比较多巴胺与上腺素作为新生儿的第一线内的疗效.
- 确定在开始治疗后60分钟内实现冲击逆转的患者比例.
主要方法:
- 随机,开放的,受控的试验.
- 纳入标准:新生儿患有耐液体败血症.
- 主要结果:在60分钟后冲击反转.
主要成果:
- 与多巴胺组相比,上腺素组的冲击逆转率更高 (31/ 40),但这种差异没有统计学意义 (p=0. 143).
- 在两组中,全因死亡率高且相似:多巴胺为87. 5%,上腺素为85%.
- 多巴胺和上腺素在冲击逆转方面没有显著的疗效差异.
结论:
- 在新生儿中,多巴胺和上腺素在60分钟内逆转败血症的疗效相等.
- 可能需要进一步的研究来探索其他治疗终点或患者子组.
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