在情绪和焦虑障碍的负面情绪处理过程中,突出网络的皮质调节
Sevil Ince1,2, Ben J Harrison3, Kim L Felmingham4
1Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia. since@student.unimelb.edu.au.
Molecular psychiatry
|August 28, 2025
概括
患有情绪和焦虑障碍的个体表现出大脑连接的改变,特别是从周水管灰色 (PAG) 到前面的岛屿缺乏抑制信号,影响情绪处理.
科学领域:
- 神经科学
- 精神病学
- 大脑成像
背景情况:
- 处理负面情绪事件的功能障碍是情绪和焦虑障碍的标志.
- 在突出网络 (SN) 的异常功能,包括前面的岛屿,是涉及的.
- 像桃体和水管灰色 (PAG) 这样的皮层区域对于情绪处理和神经元协调至关重要.
研究的目的:
- 在负面情绪处理过程中研究杏仁体,PAG和SN之间的神经相互作用.
- 确定与情绪和焦虑障碍相关的大脑连接的差异.
主要方法:
- 使用超高场7特斯拉功能磁共振成像 (fMRI) 的动态因果模型 (DCM).
- 分析了37名情绪/焦虑障碍患者和37名健康对照者的数据,
主要成果:
- 在两组中发现了杏仁体,PAG和SN之间的双向相互作用.
- 在健康对照组中,PAG对前胰岛的抑制作用是不存在的.
- 这种PAG-to-insula连接预测了诊断状态,负面影响,抑郁和压力.
结论:
- 改变PAG-to-anterior insula抑制是一个关键的神经机制,有助于情绪和焦虑障碍的突出性归因.
- 这些发现突显了PAG-SN相互作用在情感失调中的作用.
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